A selection of research studies where our instruments have been used Feb 2008
Links to references and instruments used shown in blue
1. G. Troy Smith, Harold H. Zakon (2000) “ Pharmacological
characterization of ionic currents that regulate the pacemaker rhythm in a
weakly electric fish”. Journal of Neurobiology 42, 2, 270-286. MPRE8:
[http://www.jbc.org/cgi/content/full/279/37/38448]
2. Berenice Venegas , Javier González-Damián, Heliodoro Celis and Iván
Ortega-Blake (2003). “Amphotericin B Channels in the Bacterial Membrane: Role
of Sterol and Temperature”. Biophys. J.85:2323-2332. TC2BIP: [http://www.biophysj.org/cgi/content/abstract/85/4/2323]
3. Xiaoping Wan, Shenghan Chen, Azita Sadeghpour, Qing Wang, and Glenn E. Kirsch (2001). “Accelerated inactivation in a mutant Na+ channel associated with idiopathic ventricular fibrillation”. Am J Physiol Heart Circ Physiol 280: H354-H360.
4.Edwin Janssen, Jan Kuiper, Denice Hodgson, Leonid V. Zingman, Alexey E. Alekseev, Andre Terzic and Bé Wieringa (2004) “Two structurally distinct and spatially compartmentalized adenylate kinases are expressed from the AK1 gene in mouse brain”. Molecular and Cellular Biochemistry 256,1-2, 59-72
5. G. Iribe, P.J. Cooper, M. Lei and P. Kohl (2004) “Diastolic stretch
enhances reloading of the Ca2+-depleted sarcoplasmic reticulum in Guinea pig
ventricular myocytes via a streptomycin-independent pathway”. J Physiol 557PPC13.cFlow, MPRE8:
[http://www.physoc.org/publications/proceedings/archive/article.asp?ID=J%20Physiol%20557PPC13]
6. Hans Meves, Jürgen R Schwarz and Iris Wulfsen (1999) “Separation of
M-like current and ERG current in NG108-15 cells”. Br J Pharmacol 127:
1213-1223. [http://www.nature.com/bjp/journal/v127/n5/abs/0702642a.html]
7. Zsolt A Nagy, László Virág, András Tóth, Péter Biliczki, Károly
Acsai, Tamás Bányász, Péter Nánási, Julius Gy Papp and András Varró (2004)
“Selective inhibition of sodium-calcium exchanger by SEA-0400 decreases early
and delayed afterdepolarization in canine heart”. Br J Pharmacol 2004 143:
827-831. [http://www.nature.com/bjp/journal/v143/n7/abs/0706026a.html]
8. Ravi K. Sawhney, Jonathon Howard (2004), “Molecular dissection of
the fibroblast-traction machinery” Cell Motility and Cytoskeleton, 58, 3,
175-185.[http://www3.interscience.wiley.com/cgi-bin/abstract/108066120/ABSTRACT]
9. Soleng, A. F., Baginskas, A., Andersen, P. & Raastad, M. (2004) “Activity-dependent excitability changes in hippocampal CA3 cell Schaffer axons.” The Journal of Physiology 560 (2), 491-503.
10. Graeme Lowe (2002) “Inhibition of Backpropagating Action Potentials in Mitral Cell Secondary Dendrites” The Journal of Neurophysiology 88, 1, 64-85 TC2BIP, HI-XX: [http://jn.physiology.org/cgi/content/full/88/1/64.pdf]
11. Chee Chew Lim, Michiel H. B. Helmes, Douglas B. Sawyer, Mohit Jain, and Ronglih Liao (2001) “High-throughput assessment of calcium sensitivity in skinned cardiac myocytes”. Am J Physiol Heart Circ Physiol 281: 2, H969-H974.[http://ajpheart.physiology.org/cgi/content/full/281/2/H969]
12. Cynthia A. Carnes and Spencer J. Dech (2002). “Effects of dihydrotestosterone on cardiac inward rectifier K+ current”. International Journal of Andrology 25,4, 210-214
13. Hervé Schaffhauser, Blake A. Rowe, Sylvia Morales, Laura E. Chavez-Noriega, Ruoyuan Yin, Christine Jachec, Sara P. Rao, Gretchen Bain, Anthony B. Pinkerton, Jean-Michel Vernier, Linda J. Bristow, Mark A. Varney, and Lorrie P. Daggett (2003). “Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2”. Mol Pharmacol 64:798-810.
14. “Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2”. Mol Pharmacol 64:798-810.
15. K. M. Dibb, C. L. Hagarty, A. S. I. Loudon, and A. W. Trafford
(2005) “Photoperiod-dependent modulation of cardiac excitation contraction
coupling in the Siberian hamster”Am J Physiol Regul Integr Comp Physiol 288,
R607-R614. TC2BIP, MPRE8, cFlow:
[http://ajpregu.physiology.org/cgi/content/abstract/288/3/R607]
16. Jixin Wang, Joseph J. Salata and Paul B. Bennett (2003) “Saxitoxin Is a Gating Modifier of hERG K+ Channels” Journal of General Physiology 121, 6, 583-598.
17. Scott F. Beacha and A. Wayne Vog (1999) “Spermatid Translocation
in the Rat Seminiferous Epithelium: Coupling Membrane Trafficking Machinery to
a Junction Plaque1”. Biology of
Reproduction 60, 1036-1046. TC2BIP:
[http://www.biolreprod.org/cgi/content/full/60/4/1036]
18. Matthew K. Lancaster, Sandra A. Jones, Simon M. Harrison and Mark
R. Boyett (2004). “Intracellular Ca2+ and pacemaking within the rabbit
sinoatrial node: heterogeneity of role and control”. The Journal of Physiology 556,2, 481. cFlow, TC2, MPRE8: [http://jp.physoc.org/cgi/content/full/556/2/481]
19. K. van Acker, B. Bautmans, G. Bultynck, K. Maes, A. F. Weidema, P. de Smet, J. B. Parys, H. de Smedt, L. Missiaen, and G. Callewaert (2000). “ Mapping of IP3-Mediated Ca2+ Signals in Single Human Neuroblastoma SH-SY5Y Cells: Cell Volume Shaping the Ca2+ Signal”. J Neurophysiol 83: 1052-1057. MPRE8: [http://jn.physiology.org/cgi/content/full/83/2/1052}
20. Ravi K. Sawhney and Jonathon Howard (2002). “Slow local movements of collagen fibers by fibroblasts drive the rapid global self-organization of collagen gels” . The Journal of Cell Biology, 157, 6, 1083-1092.
21. Megan M. McNulty, and Dorothy A. Hanck (2004) “State-Dependent Mibefradil Block of Na+ Channels “. Mol Pharmacol 66:1652-1661. cFlow: [http://molpharm.aspetjournals.org/cgi/content/full/66/6/1652]
22. Peng Chen, Tzyh-Chang Hwang and Kevin D. Gillis (2001) “The Relationship between cAMP, Ca2+, and Transport of CFTR to the Plasma Membrane”. The Journal of General Physiology, 118, 2, 135-144. cLevel: [http://www.jgp.org/cgi/content/full/118/2/135]
23. Olivier Poirot, Marija Vukicevic, Anne Boesch, and Stephan Kellenberger (2004). “Selective Regulation of Acid-sensing Ion Channel 1 by Serine Proteases”. J. Biol. Chem., 279, 37, 38448-38457.
24. Zhi-Hao Zhang, John A. Johnson, Long Chen, Nabil El-Sherif, Daria Mochly-Rosen, , Mohamed Boutjdir (1997). “C2 Region–Derived Peptides of ß-Protein Kinase C Regulate Cardiac Ca2+ Channels”. Circulation Research, 80:720-729.
25. Lih Chyuan Ng, Alison M. Gurney (2001). “Store-Operated Channels Mediate Ca2+ Influx and Contraction in Rat Pulmonary Artery” Circulation Research. 89:923. cFlow, MPRE8: [http://circres.ahajournals.org/cgi/content/full/89/10/923]
26. Jun Yamazaki, , Joseph R. Hume (1997). “ Inhibitory Effects of Glibenclamide on Cystic Fibrosis Transmembrane Regulator, Swelling-Activated, and Ca2+-Activated Cl- Channels in Mammalian Cardiac Myocytes” Circulation Research. 81:101-109.
27. Loren C. Denlinger, Julie A. Sommer, Karen Parker, Lalitha
Gudipaty, Philip L. Fisette, Jyoti W. Watters, Richard A. Proctor, George R.
Dubyak and Paul J. Bertics (2003). “Mutation of a Dibasic Amino Acid Motif
Within the C Terminus of the P2X7 Nucleotide Receptor Results in Trafficking
Defects and Impaired Function”. The
Journal of Immunology, 171: 1304-1311. MPRE8, cFlow
[http://www.jimmunol.org/cgi/content/full/171/3/1304]
28. Pasqualina Castaldo, Patrizia Stefanoni, Francesco Miceli, Giangennaro Coppola, Emanuele Miraglia del Giudice, Giulia Bellini, Antonio Pascotto, James R. Trudel, Neil L. Harrison, Lucio Annunziato, and Maurizio Taglialatela (2004) “A Novel Hyperekplexia-causing Mutation in the Pre-transmembrane Segment 1 of the Human Glycine Receptor 1 Subunit Reduces Membrane Expression and Impairs Gating by Agonists”. J . Biol. Chem., 279, 24, 25598-25604. MPRE8, cFlow: [http://www.jbc.org/cgi/content/full/279/24/25598]
29. S. De Marchis, A. Fasolo, M. Shipley, A. Puche (2001) “Unique
neuronal tracers show migration and differentiation of SVZ progenitors in
organotypic slices” . Journal of Neurobiology 49, 4 , 326-338.[http://www3.interscience.wiley.com/cgi-bin/abstract/88010691/ABSTRACT]
30. A. F. Soleng, K. Chiu and M. Raastad (2003) “Unmyelinated axons in the rat hippocampus hyperpolarize and activate an H current when spike frequency exceeds 1 Hz”. J. Physiol, 552.2, 459-470. ChenTC2BIP: [http://jp.physoc.org/cgi/content/full/552/2/459]
31. Andriy E. Belevych, Sunita Warrier, and Robert D. Harvey (2002)
“Genistein Inhibits Cardiac L-Type Ca2+ Channel Activity by a Tyrosine
Kinase-Independent Mechanism “. Molec. Pharm. 62, 3, 554-565. cFlow, MPRE8,TC2,:
[http://molpharm.aspetjournals.org/cgi/content/full/62/3/554]
32. Sarah S. Garber and Mary
M. Hoffman (2002) “Cl- and Glutamate- Competition for a Volume-Regulated Anion
Channel” Biol. Bull. 203: 194-195. [http://www.biolbull.org/cgi/content/full/203/2/194]
33. Torben R Neelands, Michael F Jarvis, Ping Han, Connie R Faltynek and Carol S Surowy (2005) “Acidification of rat TRPV1 alters the kinetics of capsaicin responses” Mol Pain. 2005; 1: 28. MPRE8: [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1266034
34. Baerbel Rohrer, Roman Blanco, Robert E. Marc, Marcia B. Lloyd,
Dean Bok, David M. Schneeweiss and Louis F. Reichardt (2004)“Functionally
intact glutamate-mediated signaling in bipolar cells of the TRKB knockout mouse
retina” Visual Neuroscience, 21, 703–713. [http://prometheus.med.utah.edu/~marclab/Marc_Rohrer_VN_2005.pdf]
35. Asako Kamada, Hisao Nagaya, Taku Tamura, Masataka Kinjo, Hai-Ying
Jin, Toshiharu Yamashita, Kowichi Jimbow, Hideo Kanoh, and Ikuo Wada (2004) “Regulation of Immature Protein
Dynamics in the Endoplasmic Reticulum” J. Biol. Chem., 279, 20, 21533-21542. mTC:
[http://www.jbc.org/cgi/content/full/279/20/21533]
36. Michiel Helmes, Chee Chew Lim, Ronglih Liao, Ajit Bharti, Lei Cui
and Douglas B. Sawyer (2003) “Titin Determines the Frank-Starling Relation in
Early Diastole” Journal of General Physiology, 121, 2. MPRE8, cFlow:
[http://www.jgp.org/cgi/content/full/121/2/97]
37. C.J. Mathews A1, J.A. Tabcharani A1, J.W. Hanrahan (1998) “The CFTR Chloride Channel: Nucleotide
Interactions and Temperature-dependent Gating” Membrane Biology, 163, 1. 55-66.
[http://www.springerlink.com/(gbd0txupp0152d552rj0vryx)/app/home/contribution.asp?referrer=parent&backto=issue,7,8;journal,134,538;linkingpublicationresults,1:100360,1]
38. C B Eap, S Crettol, J-S Rougier, J
Schlapfer, L Sintra Grilo, J-J Daglon, J Besson, M Croquette-Krokar, P-A
Carrupt, H Abriel, CB Eap and H Abriel (2007) “Stereoselective Block
of hERG Channel by (S)-Methadone and QT Interval Prolongation in CYP2B6 Slow
Metabolizers” Clinical
Pharmacology & Therapeutics 81, 719 – 728. TC2BIP
[http://www.nature.com/clpt/journal/v81/n5/abs/6100120a.html]
39. Erika D. Eggers, Maureen A.
McCall, Peter D. Lukasiewicz (2007)
”Presynaptic inhibition differentially shapes transmission in distinct
circuits in the mouse retina” The Journal of Physiology 582 (2), 569–582. TC2BIP [http://www.blackwell-synergy.com/doi/abs/10.1113/jphysiol.2007.131763]
40. Rajarsi Mandal, Vijay Kumar Kutala, Mahmood Khan, Iyyapu K. Mohan,
Saradhadevi Varadharaj, Arun Sridhar, Cynthia A. Carnes, Tamás Kálai, Kálmán
Hideg, and Periannan Kuppusamy (2007) “N-Hydroxy-pyrroline Modification of
Verapamil Exhibits Antioxidant Protection of the Heart against
Ischemia/Reperfusion-Induced Cardiac Dysfunction without Compromising Its
Calcium Antagonistic Activity”. JPET
323:119-127. [http://jpet.aspetjournals.org/cgi/content/abstract/323/1/119]
41. Bruce R. Bianchi, Rachid El Kouhen, Torben R.
Neelands, Chih-Hung Lee, Arthur Gomtsyan, Shirish N. Raja, Sriajan N.
Vaidyanathan, Bruce Surber, Heath A. McDonald, Carol S. Surowy, Connie R.
Faltynek, Robert B. Moreland, Michael F. Jarvis, and Pamela S. Puttfarcken
(2007) “[3H]A-778317 [1-((R)-5-tert-Butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]:
a Novel, Stereoselective, High-Affinity Antagonist Is a Useful Radioligand for
the Human Transient Receptor Potential Vanilloid-1 (TRPV1) Receptor”. JPET
323:285-293. [http://jpet.aspetjournals.org/cgi/content/abstract/323/1/285]
42. David L. Brody, Christine Mac
Donald, Chad C. Kessens, Carla Yuede, Maia Parsadanian, Mike Spinner, Eddie
Kim, Katherine E. Schwetye, David M. Holtzman, Philip V. Bayly (2007).
“Electromagnetic Controlled Cortical Impact Device for Precise, Graded Experimental
Traumatic Brain Injury” Journal of Neurotrauma. 2007, 24(4): 657-673. [http://www.liebertonline.com/doi/abs/10.1089/neu.2006.0011]
43. Erika D. Eggers and Peter D. Lukasiewicz (2005) “GABAA,
GABAC and glycine receptor-mediated inhibition differentially
affects light-evoked signalling from mouse retinal rod bipolar cells (2006) J.
Physiol. TC2BIP
[http://jp.physoc.org/cgi/content/full/572/1/215]
44. M. Danilo Boada and C Jeffery Woodbury
(2007) “Physiological Properties of Mouse Skin Sensory Neurons Recorded
Intracellularly In Vivo: Temperature Effects on Somal Membrane Properties “.J Neurophysiol (May 30, 2007).
doi:10.1152/jn.00264.2007. [http://jn.physiology.org/cgi/content/abstract/00264.2007v1]
45. Gentaro Iribe, Michiel Helmes
and Peter Kohl (2007) “Force-length relations in isolated intact cardiomyocytes
subjected to dynamic changes in mechanical load” Am J Physiol Heart Circ
Physiol 292: H1487-H1497. [http://ajpheart.physiology.org/cgi/content/abstract/292/3/H1487]
46. John C. Gant, Michelle M. Sama, Philip W. Landfield, and Olivier
Thibault (2006).”Early and Simultaneous Emergence of Multiple Hippocampal
Biomarkers of Aging Is Mediated by Ca2+-Induced Ca2+
Release “.The Journal of Neuroscience 26(13):3482-3490 TC2BIP [http://www.jneurosci.org/cgi/content/full/26/13/3482]
47. Olivier Thibault, Robert Hadley, and Philip W.
Landfield (2001) “Elevated Postsynaptic [Ca2+]i
and L-Type Calcium Channel Activity in Aged Hippocampal Neurons: Relationship
to Impaired Synaptic Plasticity “The Journal of Neuroscience, 21(24):9744-9756. [http://www.jneurosci.org/cgi/content/full/21/24/9744]
48. Mo Yang and
Xin Zhang (2006) “A novel impedance assay for cardiac myocyte
hypertrophy sensing “. Sensors and
Actuators A: Physical Volume 136, Issue 2, 16 May 2007, Pages
504-509. MPRE8, mTCII, cFlow
[http://people.bu.edu/XINZ/pdf/SNA5558.pdf]
49. J. L. Kenyon (2000) “The reversal potential of Ca2+-activated
Cl- currents indicates that chick sensory neurons accumulate
intracellular Cl- “Neuroscience
Letters, Volume 296,
Issue 1, 15 December 2000, Pages 9-12. [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0G-41SCDR3-3&_user=10&_coverDate=12%2F15%2F2000&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=3e7a2a1582b8eb6d21d9096243cd797c]
50. Ayako
Takeuchi1,2, Shuji Tatsumi1,2, Nobuaki Sarai1,2,
Keisuke Terashima1,3, Satoshi Matsuoka1,2, and Akinori
Noma (2006) “Ionic Mechanisms of Cardiac Cell Swelling Induced by Blocking Na+/K+
Pump As Revealed by Experiments and Simulation” JGP, Volume
128, Number 5, 495-507. [http://www.jgp.org/cgi/content/abstract/128/5/495?ck=nck]
51. Li-Ting Chien
and H. Criss Hartzell (2007) “Drosophila
Bestrophin-1 Chloride Current Is Dually Regulated by Calcium and Cell Volume”
The Journal of General Physiology, Vol. 130, No. 5, 513-524 [http://www.jgp.org/cgi/content/abstract/130/5/513]
52. M. Lynne McAnelly *, Harold H. Zakon (2007) “Androgen modulates the kinetics of
the delayed rectifying K+ current in the electric organ of a weakly
electric fish” Developmental Neurobiology, Vol 67 Issue 12 , pp1589-1597. [http://www3.interscience.wiley.com/cgi-bin/abstract/114277996/ABSTRACT?CRETRY=1&SRETRY=0]
53. Craig S. Nunemaker, Min Zhang, and Leslie S. Satin (2004)
“Insulin Feedback Alters Mitochondrial Activity Through an ATP-sensitive K+
Channel–Dependent Pathway in Mouse Islets and ß-Cells” Diabetes 53:1765-1772. TC2BIP, [http://diabetes.diabetesjournals.org/cgi/content/full/53/7/1765]
54. P. D. Thuta, D. Wrigleya and M. S. Gold (2003) “Cold
transduction in rat trigeminal ganglia neurons in vitro”. Neuroscience
Volume 119, Issue 4, Pages 1071-1083. CH [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0F-48WPDG3-6&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=4343831fb3b3588d58d7f12f9b1c9753]
55. Daniel Sigg, Francisco Bezanilla, and Enrico Stefani (2003) “Fast gating in the Shaker K+ channel and the energy landscape of activation”. Proc Natl Acad Sci , 100(13): 7611–7615. TC2BIP, [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=164634]
56. Jamie I. Vandenberg,, Anthony Varghese, Yu Lu, Jane A.
Bursill, Martyn P. Mahaut-Smith, and Christopher L.-H. Huang (2006) “Temperature
dependence of human ether-a`-go-go-related gene K currents” Am J Physiol Cell
Physiol 291: C165–C175. TC2BIP[http://ajpcell.physiology.org/cgi/reprint/291/1/C165.pdf]
57. Jixin Wang, Kimberly Della Penna, Hao Wang, Jerzy Karczewski, Thomas M. Connolly, Kenneth S. Koblan, Paul B. Bennett, and Joseph J. Salata (2003) “Functional and pharmacological properties of canine ERG potassium channels” Am J Physiol Heart Circ Physiol 284: H256-H267 TC2BIP, [http://ajpheart.physiology.org/cgi/content/full/284/1/H256]